My brain by Digital Shotgun
As the incidence of neurodegenerative diseases increases with the oldest baby boomers entering their early 60’s this year, it has become crucial to understand the mechanisms behind the brain and neuronal degeneration seen in Alzheimer’s and Parkinson’s disease. One in three Canadians will be affected by a disease, disorder, or injury of the brain, spinal cord or nervous system at some point in their lives, according to Neuroscience Canada. Furthermore, the global burden of neurodegenerative diseases is estimated to be over $350B USD already, both in direct and indirect costs.
Thus, the recent news that researchers at Hebrew University in Jerusalem have succeeded in watching the formation of new neurons (neurogenesis) in the brain in real time and in vivo is amazing indeed. Published in Nature Neuroscience, Dr. Adi Mizrahi combined microscopic imaging techniques with virus gene technology to watch undifferentiated olfactory neurons differentiate and grow in the brains of mice.
Researchers will now be able to study the mechanisms underlying neurogenesis more clearly. In addition to this, drug development companies may be able to introduce drugs faster into the market as preclinical models will be better translated into clinical trials. Drugs and toxins can be tested in real time and in vivo to determine optimal dose ranges.
“This has great significance for the future of brain research,” said Dr. Mizrahi, since “the structural and functional complexity of nerve cells remains one of the biggest mysteries of neuroscience, and we now have a model to study this complexity directly.â€?
Read more about this study: Hebrew University scientist observes brain cell development in “real time”.